Photios Ketsetzis was born in Xanthi, Greece in 1945. He studied at the Ecclesiastical School of Xanthi. Simultaneously, he studied Byzantine Ecclesiastical Chant under the tutelage of Mr. Demetrios Sourlatzis and Trasyboulos Stanitsas. He presently holds five degrees in his field, two of which are of the Masters level.

As a professor of Byzantine Ecclesiastical Music, he has served at various schools, lycaea and conservatories. These include, among others: the Ecclesiastical Phrontistirion of Athens, the Ecclesiastical Lyceum of Tinos, the Ecclesiastical Lyceum of Corinth, Anotera Ecclesiastical Academy of Athens, and most recently at Hellenic College/Holy Cross Greek Orthodox School of Theology.

Mr. Ketsetzis has also served as a Protopsalti (Head Chanter) since 1960, in various churches throughout Greece. Among these the most noted are: Church of the Transfiguration, Xanthi; Church of the Birth of the Theotokos, Piraeus; Saint George Church, Athens; Saint Basil Church, Athens; Saint Spyridon Church, Piraeus; The Cathedral of the Annunciation of the Theotokos, Tinos; Church of the Holy Trinity, Ambelokipon, Athens; and the Chapel of the Holy Cross, Brookline, Massachusetts.

As a director and conductor of Byzantine Choirs, Mr. Ketsetzis has organized and directed choirs wherever he taught. These choirs have participated in numerous concerts and performances with much success. In 1986, he founded, on his own initiative, the "Byzantine Choir Halandriou" which has formally been recognized by the government of Greece as a Society of Fine Arts. The members of the Society have also made him the permanent director of this choir. Most recently, Mr. Ketsetzis has been at the helm of the choir of the Archdiocesan Theological School in Brookline. Since his arrival, the choir has had a tremendous impact on Orthodox musical and liturgical circles.

Mr. Ketsetzis has offered numerous lectures and published articles on the theme of Byzantine music. He has also participated in various conferences of musicology. He is a prolific composer of hymns using Byzantine parasymantics (notation). He has served as the spotlight in numerous radio and television programs, and has recorded and produced upwards of 30 cassettes with hymns of Byzantine music.

Finally, Mr. Ketsetzis has been honored with numerous awards and distinctions, most notably was his elevation to the office of Archon Protopsaltis of the Holy Archdiocese of America in May 1995 by His Eminence, Archbishop Iakovos.